Retinoic Acid Receptor-γ in Human Epidermis Preferentially Traps All-Trans Retinoic Acid as its Ligand Rather Than 9-cis Retinoic Acid
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چکیده
منابع مشابه
Isomerization of all-trans-retinoic acid to 9-cis-retinoic acid.
The discovery of the biological activity of 9-cis-retinoic acid raises questions as to its mode of biosynthesis. A simple mechanism involves the direct isomerization of all-trans-retinoic acid to 9-cis-retinoic acid. It is shown here that bovine liver membranes, but not supernatant fractions, can isomerize all-trans-retinoic acid into 9-cis-retinoic acid and 13-cis-retinoic acid. The concentrat...
متن کاملNovel retinoic acid, 9-cis retinoic acid, in combination with all-trans retinoic acid is an effective inducer of differentiation of retinoic acid-resistant HL-60 cells.
Recent studies have shown that a high proportion of patients with acute promyelocytic leukemia (APL) achieve complete remission after treatment with all-trans retinoic acid (RA). Nevertheless, despite an initial good response, most patients that received continuous treatment with all-trans RA relapse and develop RA-resistant disease. The 9-cis RA is a high-affinity ligand for retinoid X recepto...
متن کاملAll-trans-retinoic acid: measurement
A quantitative determination of physiological levels of all-trans-retinoic acid (vitamin A acid) in human serum has been developed. A double-phase extraction of 3.5 ml of serum followed by a specific and sensitive high performance liquid chromatography procedure allowed measurement of levels down to 1 ng/ml. Serum concentrations in 37 fasting volunteers ranged from 2.7 to 4.2 ng/ml and fitted a...
متن کاملEffects of Novel Retinoic Acid Compound, 9-cis-Retinoic Acid, on Proliferation, Differentiation, and Expression of Retinoic Acid Receptor-a
Retinoic acid modulates proliferation and differentiation of a wide variety of normal and leukemic cells through two distinct families of transcriptional factors: the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs). A stereoisomer of retinoic acid, 9-cis-retinoic acid, is a highaffinity ligand for RXR and binds efficiently to RAR. In contrast, all-trans-retinoic acid interact...
متن کاملRapid Publication All-trans Retinoic Acid Modulates the Retinoic Acid Receptor-a in Promyelocytic Cells
We have recently demonstrated that all-trans retinoic acid (RA), the active metabolite of vitamin A, is an efficient alternative to chemotherapy in the treatment of acute promyelocytic leukemia (AML3). We have further shown that, in these AML3 cells, the gene of the retinoic acid receptor-a (RARa) is translocated from chromosome 17 to chromosome 15, and fused to a new gene, PLM. This results in...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1998
ISSN: 0022-202X
DOI: 10.1046/j.1523-1747.1998.00112.x